Repaglinide (Oral Route)

US Brand Names

Prandin

Description

Repaglinide is used to treat type 2 diabetes. When Eriactalis you have type 2 diabetes, insulin is still being produced by your pancreas. Sometimes the amount of insulin you produce may not be enough or your body may not be using it properly and you may still need more. Repaglinide works by causing your pancreas to release more insulin into the blood stream. Repaglinide may be used alone or with another oral diabetes medicine called metformin.

This medicine is available only with your doctor's prescription.

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of repaglinide in children with use in other age groups.

Geriatric

This medicine has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults. However, the first signs of low blood sugar are not easily seen or do not occur at all in older patients. This may increase the chance of low blood sugar developing during treatment.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Drug Interactions

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Gemfibrozil

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Itraconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acebutolol
• Alprenolol
• Atenolol
• Betaxolol
• Bevantolol
• Bisoprolol
• Bitter Melon
• Bucindolol
• Carteolol
• Carvedilol
• Celiprolol
• Clarithromycin
• Clorgyline
• Cyclosporine
• Deferasirox
• Dilevalol
• Eltrombopag
• Esmolol
• Fenugreek
• Glucomannan
• Guar Gum
• Iproniazid
• Isocarboxazid
• Ketoconazole
• Labetalol
• Levobunolol
• Mepindolol
• Metipranolol
• Metoprolol
• Moclobemide
• Nadolol
• Nebivolol
• Nialamide
• Oxprenolol
• Pargyline
• Penbutolol
• Phenelzine
• Pindolol
• Procarbazine
• Propranolol
• Psyllium
• Rifampin
• Rifapentine
• Selegiline
• Sotalol
• St John's Wort
• Talinolol
• Telithromycin
• Tertatolol
• Timolol
• Toloxatone
• Tranylcypromine
• Trimethoprim

Other Interactions

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Infection or
• Ketones in the blood (diabetic ketoacidosis) or
• Surgery or
• Trauma or
• Type 1 (insulin-dependent) diabetes or
• Unusual stress—Insulin may be needed to control diabetes in patients with these conditions

• Kidney disease or
• Liver disease—Higher blood levels of repaglinide may occur; this may change the amount of medicine you need

• Underactive adrenal gland or
• Underactive pituitary gland or
• Undernourished condition or
• Weakened physical condition—Patients with these conditions may be more likely to develop low blood sugar while taking repaglinide

General information

Prandin medication is prescribed for treating Vistagra type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus). Its generic name is repaglinide. Sold in the USA as Prandin, repaglinide is supplied by Novo Nordisk. Prandin medicine is used in combination with a special diet and exercise in adults who cannot manage diabetes by diet, exercise, or anti-diabetic medications alone.  Prandin can be used in combination with other anti-diabetic drugs.

How Prandin Works

Prandin refers to the class of meglitinide anti-diabetic drugs. It stimulates the release of insulin from the pancreas by opening the calcium channels of the pancreas beta cells. The increase in insulin release lowers the blood sugar levels. The reason why we do not use Prandin for diabetes mellitus of the 1^sttype is that the pancreas in such condition cannot release insulin at all, which cannot be changed by any Prandin mg dose.

As proved by the clinical trials, there is a link between Prandin and weight gain. Those patients that started Prandin treatment after previous hypoglycemic treatment experienced an average weight gain of 3,3% (of not previously treated by sulfonylurea medications).

How Should I Use Prandin

Prandin diabetes treatment should be received according to the doctor’s prescription. This is what you should know about taking your prescribed Prandin mg dose before you purchase Prandin:

• Prandin is taken by mouth 15-30 minutes before each meal.
• If you skip a meal, you should skip your Prandin mg dose as well.
• If you plan to have an extra meal, you should take an extra Prandin mg dose.

Compliance with your Prandin dosage regimen should be taken very seriously, as it has a direct impact on the state of your health.

You can buy Prandin tablets in the following forms:

• Prandin 0,5 mg
• Prandin 1 mg
• Prandin 2 mg

Prandin 0,5 mg is usually prescribed to those patients who have never received anti-diabetic treatment before or have hemoglobin A 1c measurements less than 8%. Those who have already been treated by anti-diabetic drugs and have the hemoglobin A 1c measurements more than 8%will most probably be prescribed to receive Prandin 1 mg or Prandin 2 mg. Prandin 4 mg is the maximum dose that can be taken before one meal. Prandin max dose for one day is 16 mg.

What if I miss a dose? If you miss your prescribed Prandin mg dose, you need to skip it and continue treatment according to the regular Prandin dosage regimen. You can take the misses dose in case you are having an extra meal.

What happens if take a bigger dose? Prandin overdose leads to hypoglycemia with such symptoms as sweating, increased hunger, dizziness, blurred vision, etc. You should seek medical assistance immediately if you’ve taken a Prandin overdose.

How should I store my Prandin medication? Prandin should be stored in a safe place at room temperature below 77⁰ F (25⁰ C), away from humidity, moisture, and light.

Where to Buy Prandin RX

Prandin rx means that to purchase Prandin, you need to have a prescription from the doctor. With a prescription, you can easily buy Prandin 0,5 mg,Prandin 1 mg or Prandin 2 mg in a drugstore. You can also buy Prandin online in one of the numerous online drugstores that often offer an attractive Prandin price. This is the best way-out for those who are looking where to buy cheap Prandin. Our online store also offers you to buy Prandin online. It will take you only a few minutes to order Prandin from us.

Safety – learn before using

Before you purchase Prandin and start treatment, you need to learn as much details of Prandin patient safety information as possible so that to avoid the side effects and other adverse events. This information includes contraindications to Prandin therapy, medical conditions and other medications that can interact with Prandin. Read the following information carefully before you purchase Prandin from us.

Contraindications

If you have any of the following, you should not receive Prandin treatment, as it will have negative effects on your medical condition. The list of Prandin contraindications includes:

• Hypersensitivity to any components of Prandin.
• Type 1 diabetes mellitus (insulin-dependent diabetes mellitus/juvenile diabetes).
• High ketone levels associated with diabetes.
• Current gemfibrozil treatment.

You ought to inform your doctor or health provider about any of the above mentioned conditions that you have.

Alerting Medical Conditions

These are the medical conditions and diseases that may interact with Prandin. If you have any of the following, you should consult with your doctor about whether to buy Prandin or not.

• Pregnancy (current or planning) and lactation (breast-feeding).
• Current treatment with other medications, intake of food supplements and herbal preparations.
• Any allergic reactions to medicines, food, and other substances.
• History of liver or kidney problems, or acidosis.

Interaction with Other Drugs

Though Prandin can be effectively used in combination with other drugs, some groups of medications may negatively interact with Prandin. These are:

• Rifampin – may decrease the effectiveness of Prandin:.
• Drugs increasing the risk of side effects, especially the risk of hypoglycemia:
  beta blockers, gemfibrozil, imidazoles, macrolides and ketolides, monoamine oxidase inhibitors, quinolones, or salicylates.
• Insulin – may increase the risk of Prandin side effects.

Please consult with your doctor concerning Prandin treatment if you are taking or planning to take any of the above mentioned drugs.

Possible Side Effects

Like practically any other medication, Prandin may cause a number of side effects that you need to be aware of. The biggest part of diabetic patients receiving Prandin treatment experiences either no or some minor Prandin side effects. Still, some of the patients experience severe Prandin side effects that require immediate medical assistance. You need to know what these side effects are and how minor side effects differ from severe ones.

Common Minor Prandin Side Effects:

• Increased hunger.
• Increased heartbeat.
• Headache, nervousness, sweating, tiredness, tremor.
• Changes in vision.
• Diarrhea.
• Pain in joints or in the back.
• Nasal or chest congestion.

Severe Prandin Side Effects:

• Severe allergic reactions – swelling of the mouth and face, rash, breathing difficulties, etc.
• Pain in the chest.

If you experience any of the severe side effects, seek emergency medical assistance immediately. Besides, you need to contact your doctor in case diabetes symptoms become worse or do not improve.